Structural Linkage Between Ligand Discrimination and Receptor Activation by Interleukin-3

Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia

WL Kan, U Dhagat, KB Kaufmann, TR Hercus, TL Nero, AGX Zeng, J Toubia, EF Barry, SE Broughton, GA Gomez, BA Benard, M Dottore, KS Cheung Tung Shing, H Boutzen, SE Samaraweera, KJ Simpson, L Jin, GJ Goodall, CG Begley, D Thomas

2023-08-01

Leukemia stem cells (LSC) possess distinct self-renewal and arrested differentiation properties that are responsible for disease e..